for Health Care Providers
When and How to Perform Pre-Vaccination Testing - Hepatitis B
Which test to use: If testing is needed prior to vaccination, use HBsAg, HBsAb, HBcAb Total
- Pre-vaccination testing should be performed if there is a reasonable chance the patient has previously been infected with HBV or vaccinated for HBV
- Pre-vaccination testing is not always necessary but should be performed for some patient groups:
- Household, sexual, or needle contacts of hepatitis B surface antigen (HBsAg)-positive persons
- HIV-positive persons
- Persons with elevated alanine aminotransferase/aspartate aminotransferase of unknown etiology
- Hemodialysis patients
- Men who have sex with men
- Past or current persons who inject drugs
- Persons born in countries of high and intermediate hepatitis B virus (HBV) endemicity (HBsAg prevalence ≥2%)
- U.S.-born persons not vaccinated as infants whose parents were born in countries with high HBV endemicity (≥8%)
- Persons needing immunosuppressive therapy, including chemotherapy, immunosuppression related to organ transplantation, and immunosuppression for rheumatologic or gastroenterologic disorders
- Donors of blood, plasma, organs, tissues, or semen