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Viral Hepatitis and Liver Disease

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Post-Vaccination Testing for Hepatitis B

for Health Care Providers

When and How to Perform Post-Vaccination Testing - Hepatitis B

Which test to use: If testing is needed following vaccination, use quantitated HBsAb only

  • Post-vaccination testing is needed for certain groups who are at especially high risk for HBV infection
  • The purpose of post-vaccination testing is to confirm if patients have achieved adequate immune response as measured by hepatitis B surface antibody
  • Perform testing 1-2 months after final dose of the HBV vaccine series
  • Persons with HBsAb concentrations of >10 mIU/ml are considered immune
  • Post-vaccination testing is recommended for some patients:
    • Infants born to HBsAg+ women
    • Infants born to women whose HBSAg status remains unknown
    • Health care personnel and public safety workers at risk for blood or body fluid exposure
    • Hemodialysis patients
    • People living with HIV
    • Other immunocompromised persons such as hematopoietic stem-cell transplant patients or persons receiving chemotherapy
    • Sex partners of HBSAg+ persons
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